MOTS-c
Mitochondrial ORF of the 12S rRNA Type-C
Research Use Only
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MOTS-C Overview
MOTS-c is a mitochondrial-derived peptide that regulates metabolic homeostasis, improves insulin sensitivity, and enhances exercise capacity.
History
MOTS-c was first described in 2015 following the discovery of short open reading frames encoded within mitochondrial DNA. Identified as a mitochondrial-derived peptide with signaling activity, it has since been studied for its ability to activate AMPK pathways and support molecular stress resistance. This discovery expanded the understanding of mitochondria as signaling organelles beyond energy production, positioning MOTS-c as a key peptide in mitochondrial biology research.
MOTS-C Structure
CAS #: 1627580-64-6
Molecular Formula: C₁₄₉H₂₆₀N₄₆O₄₆S₂
Molecular Weight: 2171.5 g/mol
PubChem ID: 91808068
Research Findings
MOTS-c has been studied in mitochondrial, molecular, and systemic models, with research highlighting its role in mitochondrial function, AMPK pathway activation, and signaling dynamics. Studies also report activity in substrate utilization, downstream markers, and molecular stress responses in preclinical settings.
Key Areas of Research:
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Mitochondrial: AMPK, signaling, pathway dynamics
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Molecular: Mitochondrial function, stress response, remodeling
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Systemic: Signaling, resilience, viability
Together, these findings suggest broad experimental potential for MOTS-c across mitochondrial, molecular, and systemic pathways. By engaging mitochondrial biology and modulating AMPK and stress response pathways, MOTS-c provides a versatile platform for research into pathway characterization, molecular dynamics, and systemic resilience in laboratory settings.