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Amino Society Pen
≥99% Purity · HPLC verified

Research Use Only

MOTC Pen

What is MOTS-C? MOTS-C (Mitochondrial ORF of the Twelve S rRNA type-c) is a 16 amino acid peptide encoded within the 12S rRNA gene of mitochondrial DNA. First identified by the Cohen lab at USC in 2015, it has been studied in laboratory settings for its role in mitochondrial-nuclear signaling and AM…
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≥99% Purity

HPLC verified

Lab tested

HPLC + MS

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Identity

Compound Information Information Information

MOTC Pen Overview

MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene region. It is studied for its role as a signaling molecule linking mitochondrial function to cellular metabolic regulation.
CAS Number
1627580-64-6
Molecular Formula
C101H152N28O22S2
Molecular Weight
2174.6 g/mol
Composition
16-amino-acid mitochondrial-derived peptide (MOTS-c)
Half-Life
Short; minutes in circulating research models
Source
Synthetic (solid-phase peptide synthesis)
Purity
99.0% (HPLC Verified)
Form
Dual-cartridge pen (lyophilized compound + diluent in sealed cartridges, combined at time of use)
Solubility
Highly soluble in water, bacteriostatic water

History

MOTS-c was identified through genomic analysis of small open reading frames within mitochondrial DNA, revealing a previously unrecognized class of mitochondrial-derived peptides with hormone-like signaling activity, distinct from nuclear-encoded proteins.

Stability Information

Long-term

−20°C

Lyophilized powder, sealed

Reconstituted

2–8°C

Up to 30 days when refrigerated

Shipping

Room temp

Stable in transit, lyophilized

Protection

Light · Moisture

Store sealed, away from light

Research Findings

MOTS-c has been studied in laboratory and animal models of metabolic regulation, AMPK pathway signaling, and mitochondrial-nuclear communication.

Key Areas of Research:

Mitochondrial
Mitochondrial-nuclear signaling research
Metabolic
AMPK pathway and energy homeostasis studies
Cellular
Age-related metabolic research models

Together, these findings support MOTS-c's role as a research tool for studying mitochondrial-derived signaling in metabolic regulation.

Important Safety Information

All products are sold strictly for in-vitro research and laboratory use only. Not for human or veterinary consumption, ingestion, injection, inhalation, application to the skin, or any other clinical use. Not approved by the FDA for any therapeutic purpose. Intended exclusively for qualified researchers in a controlled laboratory environment. By purchasing, you acknowledge and agree to use this material in compliance with all applicable laws and your institutional protocols.